Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing

Repair of severe skin tissue injury remains a great challenge and wound infection is still formidable problem. In this study, new macroporous antibacterial gelatin/alginate (SAG)-based hydrogels for repair were designed developed based on in-situ gas foaming method ion release strategy as result Mg-Cu particles degradation in the hydrogel matrix. The addition decreased storage modulus SAG, maintained its mechanical resilience enhanced water-absorbing capability. Moreover, water vapor transmission rate SAG added with 2 wt.% (SAG-2MC) was 124% that medical gauze 804% commercial Tegaderm™ film dressing. bacterial inhibition rates SAG-2MC against S. aureus, E. coli P. aeruginosa reached 99.9% ± 0.1%, 98.7% 1.2% 98.0% 0.7%, respectively, significantly greater than those Mg particle-modified hydrogels. addition, biocompatible promoted cell migration. vivo experiment results indicated accelerated healing murine model demonstrated by higher epidermis thickness, more collagen deposition angiogenesis compared SAG-0MC, SAG-2M film. summary, have potential to modulate physiochemical biological properties reveal significant promise treatment or other soft lesions.